(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
CAS: 58-58-2
Molecular Formula: C22H31Cl2N7O5
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride - Names and Identifiers
| Name | (S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride |
| Synonyms | dihydrochloride,(s)-ethyl PUROMYCIN DIHYDROCHLORIDE 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-n,n-dimethyl-adenosin adenosine,3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-n,n-dim 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-[[12-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE (S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride |
| CAS | 58-58-2 |
| EINECS | 200-387-8 |
| InChI | InChI=1/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16?,18+,22+;;/m0../s1 |
| InChIKey | MKSVFGKWZLUTTO-NGOAXYITSA-N |
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride - Physico-chemical Properties
| Molecular Formula | C22H31Cl2N7O5 |
| Molar Mass | 544.43 |
| Melting Point | 168-170℃ |
| Boling Point | 838°C at 760 mmHg |
| Flash Point | 460.6°C |
| Water Solubility | Soluble in water |
| Solubility | Soluble in water (50 mg/ml), ethanol (~1 mg/ml), DMSO (~13 mg/ml), DMF (~14 mg/ml), |
| Vapor Presure | 8.44E-30mmHg at 25°C |
| Appearance | solution |
| Color | yellow-white |
| Merck | 14,7943 |
| BRN | 3853613 |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable. Heat sensitive. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to heat |
| MDL | MFCD00012691 |
| Use | An aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene. |
| In vitro study | The antibiotic puromycin, produced by actinoniycete and streptnyces alboniger, is used as a tool to study protein synthesis in a number of systems. Puromycin can be used to select recombinant cells from non-cultured cells. |
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | AU7355000 |
| FLUKA BRAND F CODES | 3-8-10 |
| HS Code | 29419090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in guinea pig: 600mg/kg |
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride - Reference
| Reference Show more | Lei Lei, Huang Shan, Yu Ming Hang, et al. Construction of GFP-LC3 cell line stably expressing THP-1 protein [J]. Tianjin medical journal,, 046(004):341-344. |
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride - Introduction
PuromyCln 2HCl is an aminonucleoside antibiotic, which can be used as an inhibitor of protein synthesis.
Last Update：2022-10-16 17:26:36
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